3+ day, 13+ hour ago   (361+ words) Inside Precision Medicine Surbhi Jain, PhD, MBBS Surbhi Jain, PhD, MBBS, is a staff scientist at Bio-Rad Laboratories and the R&D lead for the ddPLEX EGFR/KRAS/BRAF multiplexed droplet digital PCR panel. She is focused on developing ddPCR…...

3+ day, 13+ hour ago   (641+ words) By Jonathan D. Grinstein, PhD Could an academic laboratory build genetic medicines for diseases the traditional drug-development model leaves behind? Sena-Esteves sees that mismatch repeatedly. “I wish it wasn’t that way—that we had plenty of money and could just work…...

4+ day, 15+ hour ago   (318+ words) An analysis of nearly 1000 prostate tumor samples has revealed eight integrated mutational footprints (IMFs) that underpin the majority of genetic alterations found in prostate cancer genomes, some of which reflect clinical outcomes. Although prostate cancer has a high prevalence, the…...

1+ week, 4+ day ago   (469+ words) A new type of proton beam radiation therapy known as FLASH proton therapy is being tested in a Phase I trial in patients with relapsed head and neck cancer who are not eligible for surgery at the Perelman School of…...

1+ week, 4+ day ago   (763+ words) The genetic mechanism driving an oncogene could help determine whether a tumor responds to protein-degrading therapies, potentially providing a new consideration for selecting patients for this emerging class of cancer drugs. The results suggest that tumors in which an oncogene…...

2+ week, 4+ day ago   (1169+ words) SonoThera's founder and CEO says ultrasound could overcome genetic medicine's biggest delivery challenges, including payload size, tissue targeting, and repeat dosing By Jonathan D. Grinstein, PhD The potential is enormous because targeting is driven largely by physics rather than a biological…...

2+ week, 5+ day ago   (266+ words) For patients whose cardiovascular risk falls into a gray area, a coronary artery calcium scan may provide the additional information needed to get a clearer picture of their risk, according to a new study published in JAMA. The study examined…...

2+ week, 4+ day ago   (742+ words) A new cancer immunotherapy strategy aims to turn an abundant laboratory-grown cell source into a personalized teacher for the immune system—showing a patient’s T cells not just one tumor target, but potentially the full array of targets displayed by…...

2+ week, 4+ day ago   (562+ words) Research led by Mass General Brigham has shown that patients who receive a high incidental dose of radiotherapy (RT) to the thymus during treatment for non-small-cell lung cancer (NSCLC) have an increased risk for metastasis and death, especially if they…...

3+ week, 2+ day ago   (327+ words) The study focuses less on the primary tumor and more on what makes disseminated cancer cells grow into clinically dangerous metastases. Many TNBC patients can have their primary tumor treated successfully, but outcomes worsen sharply once the disease spreads to…...