3+ day, 10+ hour ago   (641+ words) By Jonathan D. Grinstein, PhD Could an academic laboratory build genetic medicines for diseases the traditional drug-development model leaves behind? Sena-Esteves sees that mismatch repeatedly. “I wish it wasn’t that way—that we had plenty of money and could just work…...

3+ day, 15+ hour ago   (322+ words) Scientists have found that certain chemotherapy drugs can age children’s healthy cells, causing the same amount of DNA damage in a short period that would normally accumulate over decades in middle-aged adults. Results published today in Science uncover the extent…...

4+ day, 16+ hour ago   (474+ words) A comprehensive genomic profiling study involving more than 13,000 patients has shown that targetable G12C mutations in the KRAS oncogene are rare in genitourinary cancers, potentially limiting the role of routine testing and targeted treatment in these malignancies. KRAS G12C accounts for approximately…...

4+ day, 16+ hour ago   (321+ words) European researchers have proposed a biomarker-based treatment algorithm for patients with mantle cell lymphoma that could move treatment decisions beyond age and transplant eligibility toward individualized strategies based on disease biology and treatment response. The call for a change to…...

5+ day, 14+ hour ago   (340+ words) Genetic variants commonly found in people of European descent are associated with accelerated progression of Parkinson’s disease (PD), research indicates. The findings, in JAMA Neurology, suggest common loss-of-function variants in the melanocortin 1 receptor (MC1R) gene, carried by more than 60% of individuals…...

1+ week, 2+ day ago   (368+ words) Research from Switzerland suggests that having a genetic propensity to developing the lung condition chronic obstructive pulmonary disease (COPD) can negatively impact lung development in children if they are also exposed to air pollution. COPD is a progressive condition, causing…...

1+ week, 2+ day ago   (450+ words) Reactive oxygen species are usually cast as the villains in cancer, capable of damaging DNA and promoting tumor growth. But new research shows that cancer-fighting T cells need small amounts of these molecules—and tumors may exploit that dependence to…...

1+ week, 4+ day ago   (417+ words) More than a thousand genetic variants have been linked with major personality traits, according to a meta-analysis of more than a million people. The study, in Nature, suggests that specific single nucleotide polymorphisms are associated with five main stable and…...

1+ week, 4+ day ago   (763+ words) The genetic mechanism driving an oncogene could help determine whether a tumor responds to protein-degrading therapies, potentially providing a new consideration for selecting patients for this emerging class of cancer drugs. The results suggest that tumors in which an oncogene…...

1+ week, 5+ day ago   (1065+ words) Ultragenyx's FDA-approved gene therapy for glycogen storage disease type Ia (GSD1a), Genglycos, may prevent deadly hypoglycemia for patients with specific genotypes By Jonathan D. Grinstein, PhD The consequence has been a never-ending spell of anxiety and exhaustion. “We’ve never slept through the…...