3+ day, 13+ hour ago   (641+ words) By Jonathan D. Grinstein, PhD Could an academic laboratory build genetic medicines for diseases the traditional drug-development model leaves behind? Sena-Esteves sees that mismatch repeatedly. “I wish it wasn’t that way—that we had plenty of money and could just work…...

3+ day, 18+ hour ago   (322+ words) Scientists have found that certain chemotherapy drugs can age children’s healthy cells, causing the same amount of DNA damage in a short period that would normally accumulate over decades in middle-aged adults. Results published today in Science uncover the extent…...

4+ day, 19+ hour ago   (474+ words) A comprehensive genomic profiling study involving more than 13,000 patients has shown that targetable G12C mutations in the KRAS oncogene are rare in genitourinary cancers, potentially limiting the role of routine testing and targeted treatment in these malignancies. KRAS G12C accounts for approximately…...

4+ day, 19+ hour ago   (321+ words) European researchers have proposed a biomarker-based treatment algorithm for patients with mantle cell lymphoma that could move treatment decisions beyond age and transplant eligibility toward individualized strategies based on disease biology and treatment response. The call for a change to…...

1+ week, 4+ day ago   (469+ words) A new type of proton beam radiation therapy known as FLASH proton therapy is being tested in a Phase I trial in patients with relapsed head and neck cancer who are not eligible for surgery at the Perelman School of…...

2+ week, 4+ day ago   (435+ words) Research from the Karolinska Institute in Sweden shows assessing whether breast cancer tumors are estrogen receptor (ER) positive or not is more accurately measured as a spectrum rather than just classifying them as positive or negative. The researchers used a…...

2+ week, 4+ day ago   (742+ words) A new cancer immunotherapy strategy aims to turn an abundant laboratory-grown cell source into a personalized teacher for the immune system—showing a patient’s T cells not just one tumor target, but potentially the full array of targets displayed by…...

2+ week, 4+ day ago   (562+ words) Research led by Mass General Brigham has shown that patients who receive a high incidental dose of radiotherapy (RT) to the thymus during treatment for non-small-cell lung cancer (NSCLC) have an increased risk for metastasis and death, especially if they…...

3+ week, 2+ day ago   (327+ words) The study focuses less on the primary tumor and more on what makes disseminated cancer cells grow into clinically dangerous metastases. Many TNBC patients can have their primary tumor treated successfully, but outcomes worsen sharply once the disease spreads to…...

3+ week, 3+ day ago   (401+ words) Mayo Clinic researchers have quantified the risk that pancreatic cysts will progress to pancreatic cancer based on the number of worrisome features they display. Published in Gastroenterology, the findings could help doctors better assess which cysts are most likely to…...